Probiotics against viruses; COVID-19 is a paper tiger: A Systematic Review.

BACKGROUND: Probiotics can improve immune function for prevention and management of viral infections like SARS-CoV-2 infection (COVID-19 disease). METHODS: We searched on PubMed, EMBASE, Google Scholar, Science Direct, Scopus, and Web of Science up to May 2020 to identify interventional & observational studies documenting the effects of probiotics on incidence, severity, duration, and other clinical manifestations of viral infections especially SARS-CoV-2-induced. RESULTS: From a total of 91 records, 24 studies were obtained and classified into three domains based on the efficacy of probiotics on 1) shortening the period and severity of infections (n=9), 2) incidence (n=6), and 3) Other clinical complications that may be followed by viral disorders (n=9). Identified probiotics have positive effects on the mentioned domains. CONCLUSION: Based on the evidence, some probiotic strains may be useful in SARS-CoV-2 infection; randomized trials are needed to show the facts.