Incidence evaluation of Glucose-6-Phosphate Dehydrogenase and hematological profile in Rondonia

This study consisted of evaluations of glucose-6-phosphatedehydrogenase (G6PD) deficiency and the hematologic profileof 122 individuals (69 men and 53 women) with ages varyingbetween 3 and 83 years old. The individuals, all of whom wereresidents of the rural and urban areas of Porto Velho, Rondonia,Brazil, were selected according to their acceptance to participatein the study. The data of this study were collected in the periodfrom July 2003 to August 2004. The analyses consisted of usingthe glucose NaNO2 method and complete Blood Cell count. Fourmen had G6PD deficiency (5.8% among the men and 3.3% ofthe total cases analyzed). None of the individuals with G6PDdeficiency presented malaria tested using a thick smear stainedwith Giemsa stain 20. Among the men, 19 individuals (27.5%)presented malaria with 15 infected by Plasmodium vivax and 4infected by Plasmodium falciparum. Forty-eight men (69.5%)presented with haemoglobin values of less than 14.0 g/dL and 26(37.6%) presented erythrocytary values of less than 4.5 millions/mm3. Among the women, just 2 (3.2%) presented with malaria,caused by Plasmodium vivax and 24 (45.2%) presentedhaemoglobin values less than 12.0 g/dL. Twelve (22.6%)presented erithrocytary values less than 4.0 millions/mm3.Eosinophilia was seen in 47 (68.1%) men and 34 (64.1%) women.The incidence of G6PD deficiency was significant among themale population who sought medical assistance due to fever. Asprimaquine is used in the radical treatment of malaria caused byboth vivax and falciparum infections, the risk of seriousintravascular hemolysis is significant among these individuals.The test used is very simple and has a low cost so we suggest itsadoption in routine public service laboratories in endemic areas.