SIOPEL-3 Liver Tumour Studies: hepatoblastoma and hepatocellular carcinoma

INTERVENTION: Standard risk hepatoblastoma Arm 1: Initial Treatment ‐ 1 course cisplatin. Continuation treatment ‐ 5 courses cisplatin/doxorubicin. Surgery after course 3 (if feasible). Arm 2: Initial treatment ‐ 1 course cisplatin. Continuation treatment ‐ 5 courses cisplatin. Surgery after course 3 (if feasible). CONDITION: Hepatoblastoma and hepatocellular carcinoma ; Cancer ; Malignant neoplasm of liver PRIMARY OUTCOME: Complete resection SECONDARY OUTCOME: Toxicity measures, survival and event‐free survival INCLUSION CRITERIA: 1. Diagnosis is hepatoblastoma 2. Pretext is I, II or III 3. No extrahepatic Involvement 4. Age <16 at diagnosis 5. No prior treatment 6. No primary surgery required 7. Lung CT scan performed 8. Initial serum alpha‐feta protein value obtained (greater than or 100 ng/ml)