Substrate-dependent utilization of OprM or OpmH by the Pseudomonas aeruginosa MexJK efflux pump.

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Kategorie Primary study
ZeitungAntimicrobial agents and chemotherapy
Year 2005
MexJK requires OprM for erythromycin efflux but not for triclosan efflux. Deletion of 15 OprM family outer membrane proteins (OMPs) revealed that only the TolC homolog OpmH functions with MexJK for triclosan efflux. This is the first report of natural utilization of multiple OMPs by a given resistance nodulation cell division transporter/membrane fusion protein pair.
Epistemonikos ID: e114986a2186e62e6301e01b10354019151ba2d3
First added on: Jan 06, 2023