Fluid replacement therapy for acute episodes of pain in people with sickle cell disease.

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作者 Okomo U, Meremikwu MM -More
类别 Systematic review
期刊Cochrane Database of Systematic Reviews
Year 2007
連結 Pubmed, DOI
背景和目的：在多发性硬化（MS）中没有清楚地检测到具有较高治疗效果的亚组患者。目前的工作目的是评估是否存在对治疗反应更敏感的复发性MS（RRMS）患者亚组。方法：收集所有出版的RRMS报告亚组分析治疗效果的随机临床试验。研究了两个主要结果，年龄复发率（ARR）和残疾进展。每个亚组的治疗效果被报告为相对效应（RE），定义为亚组相对于整体效果的治疗效果。进行荟萃分析以比较亚组之间的RE。结果：纳入6项试验（6693例RRMS患者）。治疗ARR明显高于老年患者（RE = 0.83 vs. RE = 1.30，P <0.001），与没有钆活性的患者相比（RE = 0.86 vs. RE = 1.15，P = 0.005） （RE = 0.96 vs. RE = 1.23，P = 0.02），残疾进展比年龄较大的受试者年轻（RE = 0.82 vs. RE = 1.28，P = 0.017）。结论：本研究正式表明，RRMS较高的治疗效果与早期（较低年龄，扩大残疾状态量表）和更活跃（较高钆活性）疾病的特征相关。
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Epistemonikos ID: 3b3fab412f496675ad5a2c0b7a848a773c790dbc
First added on: Dec 16, 2015
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