Clinical and biochemical indexes of 11 COVID-19 patients and the genome sequence analysis of the tested SARS-CoV-2

Abstract Background: At present, SARS-CoV-2 epidemic in the world rapidly spread. It is a serious global public health emergency.Methods: Here we described the clinical characteristics of 11 SARS-CoV-2 infected patients hospitalized in the Meizhou People's Hospital. And viral genome sequences of SARS-CoV-2 from these patients were analyzed.Results: Of the 11 patients, 6 cases developed fever, 9 cases developed cough, and 2 cases developed headache and chills. 4 patients (36.4%) had underlying diseases. Pneumonia is the most common complication. The most common laboratory abnormalities were decreased lymphocytopenia (LYM) and lymphocytic percentage (LYM%), decreased total protein (TP) and albumin (ALB), increased erythrocyte sedimentation rate (ESR), C reactive protein (CRP), activated partial thromboplastin time (APTT), increased fibrinogen (FIB), creatine kinase isoenzymes (CK-MB), and lactate dehydrogenase (LDH). Neutrophil (NEU) (r=0.664, P=0.026), CK-MB (r=0.655, P=0.029), blood urea nitrogen (BUN) (r=0.682, P=0.021) and SARS-CoV-2 virus cycle threshold (Ct) value were significantly correlated. Multiple sequence alignment (MSA) shows that we identified two different SNPs at positions 8781 and 28144.Conclusions: We hope that the reports of these 11 cases in our hospital will provide useful information for the diagnosis, treatment and drug development of SARS-CoV-2.