Anticholinergic therapy for chronic asthma in children over two years of age

Machine translation Machine translation
类别 Systematic review
期刊Cochrane Database of Systematic Reviews
Year 2003
連結 Pubmed, DOI, PubMed Central
目的：许多抑郁症患者对抗抑郁药物单药治疗反应迟钝。用于治疗耐药性抑郁症的一种方法是结合抗抑郁药并利用多种治疗作用机制。本评论对抗抑郁药联合使用的疗效进行了批评性评估。方法：进行了过去15年（截至2001年6月）的MEDLINE检索，辅以书目检查，以确定相关研究。用于选择研究的标准包括（1）在同行评议的期刊中发表原始数据的研究，（2）对标准治疗有部分或无反应的抑郁症的诊断，（3）两种抗抑郁药与两种用于增强抗抑郁药的药物的组合反应，（4）临床反应的结果测量，以及（5）4名或以上受试者的样本量。结果：二十七项研究（总N = 667）符合入选标准，其中包括5项随机对照试验和22项开放标签试验。在24项研究（总计N = 601）报告应答率中，总体平均反应率为62.2％。方法上的局限性包括治疗耐药抑郁症的定义和治疗反应，药物给药和不良事件报告的变异性。结论：证据有限，主要在不受控制的研究中，支持联合抗抑郁药治疗的疗效。需要进一步的具有较大样本量的随机对照试验来证明联合抗抑郁药策略对耐药抑郁症患者的疗效。
Copyright © 2010 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.
This translation has been produced by an automated software. If you wish to submit your own translation, please send it to translations@epistemonikos.org
Epistemonikos ID: fea821c482a90fb3f7cf8606f8ec58b80ad79768
First added on: Oct 11, 2011
Warning
This is a machine translation from an article in Epistemonikos.

Machine translations cannot be considered reliable in order to make health decisions.

See an official translation in the following languages: English

If you prefer to see the machine translation we assume you accept our terms of use

Warning
This is a machine translation from an article in Epistemonikos.

Machine translations cannot be considered reliable in order to make health decisions.

See an official translation in the following languages: English, Español

If you prefer to see the machine translation we assume you accept our terms of use