Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs

Machine translation Machine translation
类别 Systematic review
期刊Cochrane Database of Systematic Reviews
Year 2017
連結 Pubmed, DOI, PubMed Central
背景：讨论关节内透明质酸（IAHA）注射用于膝关节骨关节炎（KOA）的有效性。目的：通过分析IAHA与偏倚风险偏低的安慰剂试验数据，评估IAHA对KOA患者的影响，提供最高水平的证据。方法：进行系统评价和荟萃分析。研究IAHA与安慰剂（盐水溶液）注射相比，具有偏倚风险偏低（足够随机，隐蔽和双盲设计）的随机对照试验（RCT）符合条件。主要疗效指标为3个月时的疼痛强度和次要结局功能。治疗效果总结为3个月时治疗组与对照组疼痛和功能测量差异的标准平均差（SMD）。试验通过随机效应模型与DerSimonian和Laird权重进行合并。通过对森林地块和I（2）统计量的视觉探索，探讨了统计异质性。结果：共有8例RCT（2 199例随机患者）符合我们的入选标准。 IAHA显着降低疼痛强度（SMD = -0.21，95％CI（95％CI）-0.32至-0.10）和功能改善（SMD = -0.12，95％CI -0.22至-0.02）。试验显示没有异质性。结论：IAHA与安慰剂的高质量试验的荟萃分析显示，IAHA为KOA患者提供了中等但真正的益处。
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Epistemonikos ID: ee63cef9127e6e869726cda100dc5efd95acf0ab
First added on: Jun 27, 2017
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