A comparison of the efficacy of cilazapril versus cilazapril plus hydrochlorothiazide in patients with mild to moderate essential hypertension. Inhibace General Practice Study Group.

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作者
类别 Primary study
期刊European journal of clinical pharmacology
Year 1993
在一项多中心,双盲,随机在87例轻,中度高血压8周以上的基本平行组研究相比,西拉普利单药治疗的疗效和组合与氢氯噻嗪12.5毫克。经过2周的单盲安慰剂运行期间,患者接受要么西拉普利2.5毫克或2.5毫克西拉普利加12.5毫克氢氯噻嗪每日一次。西拉普利剂量在第4周增加2.5毫克至5.0毫克,如果平均坐位舒张压大于90毫米汞柱,或不超过10毫米汞柱下降。经过8周治疗后72%的患者2.5毫克西拉普利提高到88%与西拉普利5.0毫克。西拉普利加上hydrochlorothiazide,83%到2.5毫克5.0毫克西拉普利西拉普利增加96%。高响应速率低剂量西拉普利单一和氢氯噻嗪联合治疗有重要影响,为减少成本与ACE抑制剂治疗。
Epistemonikos ID: e6b7f07d8cddf2ab16495b2439e8cae55c81bef4
First added on: May 01, 2012
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