One-week triple vs. quadruple therapy for Helicobacter pylori infection - a randomized trial

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类别 Primary study
期刊ALIMENTARY PHARMACOLOGY & THERAPEUTICS
Year 2002
連結 Google Scholar, Pubmed, DOI
背景：7天包括奥美拉唑，克拉霉素和阿莫西林三联疗法已成为治疗幽门螺旋杆菌感染的首选。然而，古典翻两番奥美拉唑，四环素，甲硝唑和铋结合治疗7天，可能是三联疗法的替代方法。 目的：比较三联与四联疗法对幽门螺杆菌根除。 方法：三百三十九个消化性溃疡与幽门螺旋杆菌感染的患者被纳入研究。患者随机接受奥美拉唑20毫克，阿莫西林，1克，克拉霉素，500毫克，所有的BD，或奥美拉唑20毫克BD，氯四环素，500毫克，甲硝唑500毫克，次枸橼酸铋120毫克，所有TDS被定义为负尿素呼气试验治疗后至少2个月治愈。 结果：按协议和意向性治疗的治愈率分别为86％[95％可信区间（CI），80-91％和77％（95％CI 70-83％）三联疗法，89％（ 95％CI 82-93％）和83％（95％CI 76-88％），四联疗法。各组之间无显着差异，在治愈率，遵守或副作用。 结论：为期一周的三联和四联疗法作为第一线根除治疗时使用了类似的结果。
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Epistemonikos ID: df322ba5dd282da29e8f974049e87554bab76132
First added on: Jan 09, 2012
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