Hydrocortisone infusion for severe community-acquired pneumonia - A preliminary randomized study

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类别 Primary study
期刊AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
Year 2005
我们推测在重症社区获得性肺炎输液,氢化可的松抑制全身炎症反应,并导致早期肺炎和败血症相关的并发症减少的决议。在一个多中心临床试验,收治重症社区获得性肺炎的重症监护室(ICU)接受协议制导的抗生素治疗,并随机分配给氢化可的松注射或安慰剂。给予氢化可的松200毫克静脉输液7天10毫克/小时的速度跟着丸。主要研究终点为改善霸(O(2)):FI(O(2))(霸(O(2)):FI(O(2))> 300> / = 100增加研究项)和多器官功能障碍综合征(MODS)第8天,减少迟发性感染性休克研究的得分。46例患者进入研究。进入研究时,氢化可的松组有较低霸(O(2)):连接(O(2)),和更高的胸片评分和C-反应蛋白水平。由8天的研究,治疗的患者相比,与对照组,在PA显着改善(O(2)):FI(O(2))(P = 0.002)和胸片得分(P <0.0001),在C-反应蛋白水平显着降低(P = 0.01),MODS评分(P = 0.003),迟发性感染性休克(P = 0.001)。氢化可的松治疗与住院时间显着减少(P = 0.03)和死亡率(P = 0.009)。
Epistemonikos ID: c5d2794ef2d6452b6d90a22a40d879b100e2098e
First added on: Jul 27, 2011
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