Web-based interventions to improve mental health, general caregiving outcomes, and general health for informal caregivers of adults with chronic conditions living in the community: Rapid evidence review.

Machine translation Machine translation
类别 Systematic review
期刊Journal of medical Internet research
Year 2017
背景:骨肉瘤是最常见的原发性骨质恶性肿瘤。我们荟萃分析了改变的miRNA在骨肉瘤患者中的预后价值。方法:从MEDLINE(从开始到2016年8月)和EMBASE(从开始到2016年8月)的来源被搜索。包括具有miRNA结果的骨肉瘤和报告的生存数据的研究包括在内,两位作者独立进行数据提取。任何差异都是以协商一致方式解决的。结果是使用风险比(HRs)评估总体生存率和无事件生存率。结果:本研究共收到65篇文章全文,共有2578项研究,其中2,278例患者符合资格。随机效应模型(χ2= 113.08,p <0.00001,I2 = 79%),骨肉瘤患者的死亡人数为1.40(95%置信区间[CI] 1.01-1.94,p = 0.04) miRNA的。然而,事件汇总HR不显着(HR 0.97,0.63-1.48,p = 0.87,χ2= 72.65,p <0.00001,I2 = 79%)。在miRNA的途径分析中,miRNA449a,199-5p,542-5p具有共同的靶基因。结论:骨肉瘤患者miRNA的表达水平作为预后因子是重要的。
Epistemonikos ID: af29e5c770ae69a39ce3615b8e2ea5a9e8ff4e25
First added on: Jul 30, 2017
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