Aminophylline increases the toxicity but not the efficacy of an inhaled beta-adrenergic agonist in the treatment of acute exacerbations of asthma.

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作者 Siegel D, Sheppard D, Gelb A, Weinberg PF -More
类别 Primary study
期刊The American review of respiratory disease
Year 1985
連結 Pubmed, DOI
我们研究了40例哮喘急性发作期的3 h静脉滴注氨茶碱患者谁正在接受治疗的吸入β-肾上腺素能受体激动剂（奥西），以确定疗效。每隔一小时3小时，每个患者接受了吸入奥西。此外，患者被随机分配到治疗静脉氨茶碱或安慰剂。无论是病人，也不是房子的人员和护士照顾病人知道是否氨茶碱或安慰剂。整个研究过程中不断完善的FEV1到两个治疗组的相似程度，但与氨茶碱治疗的患者有更多的不利影响（p小于0.025，采用Mann-Whitney）。从氨茶碱，即使在严重的气道阻塞（FEV1小于0.8L）或血浆茶碱浓度小于10 mg / L病人谁提出的急诊室，有没有明显的好处我们得出这样的结论：氨茶碱静脉滴注的增加的毒性，但不是哮喘的急性发作的治疗中的功效吸入奥西。
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Epistemonikos ID: a3628a156b368d77e33aa809af69be84b64e3f90
First added on: Dec 23, 2012
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