Comparison of the effects of dietary plant sterol and stanol esters on lipid metabolism.

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类别 Primary study
期刊Nutrition, metabolism, and cardiovascular diseases : NMCD
Year 2004
連結 Pubmed, DOI
背景与目的：比较降胆固醇疗效和植物甾醇酯和stanol其他代谢的影响，这两者都是常见的高血脂饮食管理使用。方法与结果：甾醇酯和stanol和stanol酯不同摄入量相当于摄入量降胆固醇效果进行了比较，并在1 2个月，无论是在正常人和家族性高胆固醇血症患者。系统性影响评估测量植物甾醇和lathosterol则和7alpha -羟基- cholestenone，甾醇的吸收和胆固醇和胆汁酸合成血清指数分别。有在学习与1.6克总胆固醇降低3-7％（每日甾醇酯和stanol无显着差异）或低密度脂蛋白胆固醇的4-8％（），也与1.6和2.6克每天stanol 。然而，植物甾醇酯降低胆固醇的作用减弱1至2个月。这是伴随着增加，并降低血清植物甾醇的7alpha -羟基- cholestenone，尤其是在他汀类药物治疗的患者高脂饮食不采取胆汁酸sequestrants水平。结论：这些结果表明，膳食植物甾醇的吸收抑制胆汁酸合成，从而削弱了它们的降胆固醇的功效。相比之下，植物stanols降低植物甾醇的吸收和维持其降低胆固醇的功效。
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Epistemonikos ID: 82ba6c58f0c0b734cb86529a81d3bf4fa2ca7dad
First added on: Jun 08, 2011
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