Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma.

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类别 Primary study
期刊The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology
Year 1997
連結 Pubmed, DOI
茶碱抗哮喘的影响可能在哮喘的吸入性类固醇的补充。本试验的目的是研究如何增加茶碱的剂量增加一倍的比较对症保持丙酸倍氯米松（BDP）400微克x日（-1）在哮喘吸入类固醇。该试验的目的是作为一项随机，双盲，平行组研究在几个欧洲国家。茶碱加的BDP 400微克x日（-1）6周，治疗69例相比，BDP的800微X天（-1）治疗64例。平均+ /-SD血清茶碱浓度为10.1 + / -4.2毫克x长（-1）。整个研究进行了肺功能测量和患者保持每日记录呼气峰流速（PEF）的症状和沙丁胺醇​​使用。被迫在一秒钟内和PEF呼气量在6周显着增加（P <0.01）两种治疗。PEF变异减少了约30％在这两个群体。有哮喘症状和急救药物的使用显着改善（P <0.001）。治疗组之间没有显着差异。这项研究表明临床等价茶碱加丙酸倍氯米松400微克x日（-1）和丙酸倍氯米松800微克x日在患者的哮喘控制丙酸倍氯米松400微克x日（-1）（-1）。结果支持茶碱作为保类固醇剂的使用。结合低剂量吸入糖皮质激素加茶碱是一个适当的治疗中度哮喘。
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Epistemonikos ID: 75aa2f241ecb31360333f2fadc026fdd14eb846e
First added on: Mar 25, 2012
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