Association of XRCC1 Arg399Gln and OGG1 Ser326Cys polymorphisms with the risk of cervical cancer in Japanese subjects.

Machine translation Machine translation
类别 Primary study
期刊Gynecologic oncology
Year 2005
連結 Pubmed, DOI
目的：在本研究中，基因多态性，XRCC1 Arg399Gln和OGG1 Ser326Cys检查参照宫颈癌的危险在日本以人群为基础的事件病例对照研究。 方法：病例包括131宫颈癌患者87例，鳞状细胞癌（SCC）和44腺癌（ADC）或腺鳞癌（ADSC）。对照组320名健康妇女谁接受健康检查采样。 结果：在病例399GlnGln基因型频率明显高于腺癌/腺鳞癌个人较健康对照组（OR = 2.98，95％CI = 1.11-8.01，P = 0.030）。然而，没有关联表现在SCC。 OGG1的多态性Ser326Cys分析表明，宫颈癌患者和对照组之间没有差异显著。在分层分析，腺癌/腺鳞癌显著升高的风险与XRCC1 399GlnGln基因型有关非吸烟者（OR = 3.85，95％CI = 1.28-11.59，P = 0.017），但不吸烟者之中。没有基因 - 基因相互作用，观察在我们的案例科目。 结论：这是在病例Arg399Gln多态性可能是相对于宫颈腺癌/腺癌的风险的重要的第一份报告。
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Epistemonikos ID: 756be3481e0d0cd18bfcab18e5faf68a3ce4c67f
First added on: Apr 10, 2014
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