Dual-centre, double-blind, randomised trial of lymphoblastoid interferon alpha with or without steroid pretreatment in children with chronic hepatitis B.

Machine translation Machine translation
类别 Primary study
期刊Liver
Year 1995
連結 Pubmed, DOI
三十五岁以下儿童慢性HBV感染，HBV-DNA和东亚运动会的血清阳性和HBcAg在肝组织进行治疗淋巴母细胞的人α-干扰素（16例）或无（19例），强的松龙预处理。患者的双盲，随机，接受类固醇或安慰剂4周，2周后，5年或10 MU/m2干扰素12周。电子抗-E血清学转换率达到48％，远远高于自发转阴率。“泼尼松龙吸”的影响无统计学意义。在这两个群体（44％泼尼松龙/干扰素和干扰素单独的后53％），HBeAg清除。无论是治疗的反应并没有相关的治疗前血清转氨酶。HBV-DNA或组织活动的程度。干扰素的耐受性良好，副作用少比成人严重，并不会导致暂停的治疗。
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Epistemonikos ID: 72eff5385dd18ff9d3d05234dc26b0566047ee76
First added on: Nov 26, 2012
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