A 2-year follow up of babies enrolled in a European multicentre trial of porcine surfactant replacement for severe neonatal respiratory distress syndrome. Collaborative European Multicentre Study Group.

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类别 Primary study
期刊European journal of pediatrics
Year 1992
連結 Pubmed, DOI
参加了欧洲第一个多中心试验的猪表面活性剂（固尔苏）更换重症新生儿呼吸窘迫综合症，产后的增长，呼吸状态和存活婴儿的神经发育结果在矫正年龄1年和2年的评估。生还者的随访率分别为93％，1年和2年的89％。治疗组和对照组在1和2年身体的成长，持续呼吸道症状的患病率和发生重大和轻微残疾。承认固尔苏和表面活性剂，抗表面活性剂的免疫复合物的血清抗体检测在治疗和控制婴儿，滴度组之间无差异。从非幸存者组织的肺段检查发现一个比在表面活性剂治疗的控制婴儿的严重肺间质性肺气肿的发病率较高。表面活性剂治疗严重呼吸窘迫综合症，降低新生儿死亡率和空气泄漏和不增加残疾2年后。
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Epistemonikos ID: 7160203e83ca3f0eb6446ec307704efa128a3e67
First added on: Jun 26, 2012
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