Randomised, controlled trial with the trypsin-modified inactivated poliovirus vaccine: assessment of intestinal immunity with live challenge virus.

Machine translation Machine translation
类别 Primary study
期刊Vaccine
Year 1999
增强效力的类型3的组件(TryIPV)脊髓灰质炎灭活疫苗(E-IPV)进行了修改,含有胰蛋白酶处理3型脊髓灰质炎病毒(PV3),应变Saukett,。这项试验疫苗的重新分配疫苗诱导的抗体在小鼠体内模仿那些人脊髓灰质炎病毒感染后可见的。3的剂量TryIPV或E-IPV在一项随机,双盲试验组的婴儿免疫。第三剂量6个月后,在18个月的年龄,孩子们口头单价3型脊髓灰质炎病毒疫苗一剂的挑战。肠道免疫进行了评估,通过评估的长度和程度的PV3排泄的决心的PV3滴度在连续9粪便标本(2-42天后挑战)。组与组之间无显着差异的长度或病毒分泌程度被看见。结果表明,TryIPV,使用的条件下,没有更有效的诱导抗脊髓灰质炎病毒感染肠比普通的E-IPV。
Epistemonikos ID: 4a5b0cf26cd60e6ed9bb47a5d8553112dc754333
First added on: Nov 12, 2012
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