Delta neutrophil index (DNI) as a novel diagnostic and prognostic marker of infection: a systematic review and meta-analysis.

Machine translation Machine translation
类别 Systematic review
期刊Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Year 2017
連結 Pubmed, DOI
背景：涉及癌症发展的5,10-亚甲基四氢叶酸还原酶（MTHFR）多态性，但已发表的研究已经产生不一致的结果。方法：对所有已发表的有关MTHFR多态性和前列腺癌风险的病例对照研究进行搜索。结果：共有13项研究，包括5872例和6255例对照，描述了C677T基因型，其中包括2847例和3657例对照的9篇文献描述了A1298C基因型，涉及我们的荟萃分析。估计具有95％置信区间（CI）的比值比（ORs）评估MTHFR多态性与前列腺癌风险之间的关联，异质性，出版偏倚和敏感性。总体而言，荟萃分析表明，677T等位基因在隐性遗传中更有可能对前列腺癌风险（随机效应合并OR，0.78（0.64-0.96）; P = 0.016（P = 0.033，异质性研究））发挥保护作用遗传模型，在其他遗传模型中或在比较a / a与A / A纯合子中没有发现关联。我们也没有发现对高侵袭性或低侵袭性前列腺癌的影响有任何差异。没有发现MTHFR A1298C多态性与前列腺癌相关的证据。结论：MTHFR基因C677T可能对前列腺癌风险的易感性提供保护作用。
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Epistemonikos ID: 4506c1d2966dcd49d8c8f0e78bb431d67a408f96
First added on: Jun 25, 2017
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