Association between temporal lobe P-glycoprotein expression and seizure recurrence after surgery for pharmacoresistant temporal lobe epilepsy.

Machine translation Machine translation
类别 Primary study
期刊Neurobiology of disease
Year 2010
連結 Pubmed, DOI
手术建议pharmacoresistant颞叶癫痫（TLE），但发作的患者术后复发的约三分之一。P-糖蛋白是一个流出的多药转运是过度的的范围内引起癫痫发作的病状。我们假设，P-糖蛋白的表达增加，可能在癫痫发作的颞叶的pharmacoresistant癫痫术后复发的标志。我们进行了免疫组织化学从行前颞叶切除术69例，pharmacoresistant TLE病理组织学证实的海马硬化颞叶组织切除。P-糖蛋白的表达被评为三病理学家独立。惊厥复发的患者（n = 22）有更多的染色阳性的毛细血管（P = 0.001）和较高的P-糖蛋白的免疫反应性得分（P = 0.002），切除颞叶白质的毛细血管。差异仍然显着，在多变量分析（P = 0.002和0.006，分别）。结果表明，P-糖蛋白的表达可能与颞叶癫痫发作复发，手术后pharmacoresistant TLE。
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Epistemonikos ID: 3f1b7d603b54508891f3234ebfc96ffd04091860
First added on: Jan 07, 2013
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