Clonidine and cardiac surgery: haemodynamic and metabolic effects, myocardial ischaemia and recovery.

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类别 Primary study
期刊Anaesthesia and intensive care
Year 1999
連結 Pubmed, DOI
可乐定可能有在接受大手术的患者有益的影响。我们招收156例选择性冠状动脉搭桥手术，在一项双盲，随机试验。患者随机接受要么两个剂量的安慰剂（PP）或可乐定5微克/公斤（CC组）。围术期的测量包括血流动力学，麻醉和镇痛药的使用，肌酐清除率，皮质醇排泄，恢复时间和手术后的生活质量（SF-36）。总体而言，拔管时间（中位数[10-90百分位）没有显着差异：CC 7.1（3.4-18）h和PP 8.0（4.3-17）H，P = 0.70;但有一个更高的比例四小时内拔管的患者：CC 20％，与PP 8％，P = 0.038。可乐定导致了显著（P <0.01），血流动力学变化，尤其是前体外循环：心动过速和高血压的少，更多的心动过缓和低血压。可乐定与1显著（P <0.01），减少麻醉药物的使用，肌酐清除率较高，较低的皮质醇排泄和改善生活质量的某些方面。这项研究支持审议可乐定治疗的患者在接受冠状动脉搭桥手术。
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Epistemonikos ID: 3b390193ee819798035c2aacb8bf3ee72404df5f
First added on: May 02, 2012
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