Short-duration treatment of fingernail dermatophytosis: a randomized, double-blind study with terbinafine and griseofulvin. LAGOS III Study Group.

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类别 Primary study
期刊Journal of the American Academy of Dermatology
Year 1995
連結 Pubmed, DOI
背景：指甲Dermatophytic感染可以口服抗真菌药得到有效治疗，但是需要的治疗时间长，一般几个月，治愈。 目的：我们的目的是比较特比萘芬和灰黄霉素短时间的治疗功效，在指甲的管理脚气。 方法：在这项随机，双盲研究180指甲脚气患者的治疗，每天服用或特比奈芬250毫克/天，或microsized灰黄霉素，500毫克/天，12周。患者随后接受安慰剂12周，与另外24个星期的观察。真菌学检查和测量未受影响指甲的生长，药物的疗效进行了评估。 结果：在研究组收到特比奈芬发现完全治愈（P = 0.001）和39％收到灰黄霉素76％。药物的耐受性是在两个治疗组同样良好，没有任何临床相关的实验室生化值的变化。 结论：短时间的治疗脚气指甲与特比萘芬和灰黄霉素（3个月）是很好的耐受性。然而，特比奈芬具有较高的治愈率。
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Epistemonikos ID: 28c021b71163ee2dd1a5d3eb59837a0cd69dc2c1
First added on: Mar 31, 2012
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