Monotherapy or aminoglycoside-containing combinations for empirical antibiotic treatment of febrile neutropenic patients: a meta-analysis.

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作者
类别 Systematic review
期刊The Lancet infectious diseases
Year 2002
我们设置了比较与综合疗法,包括经验性治疗发热性中性粒细胞癌患者的氨基糖甙类抗生素单药治疗的疗效。我们做了29池从4795高热发作和1029菌血性发作固定和随机效应模型的一个子集的数据的随机临床试验的荟萃分析。测量结果是抗生素治疗,治疗失败定义为修改的初步分配方案或在治疗过程中死亡。在高热发作,合并比值比(OR)的单一与组合疗法的临床失败为0.88,95%CI为0.78至0.99,固定效应模型和0.87,95%CI较为保守的0.75到1.01随机效应模型。对于菌血性发作,与单一的合并OR失败是0.70固定效应模型(0.54至0.92),0.72(0.54至0.95)由随机效应模型。我们得出这样的结论:单药治疗已如氨基糖甙类抗生素经验治疗发热性中性粒细胞减少含组合有效。
Epistemonikos ID: 0a53a488503f142ef64a289d20422216f9a166f9
First added on: Jun 07, 2012
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