[Responsiveness of the Expanded Disability Status Scale (EDSS) to disease progression and therapeutic intervention in progressive forms of multiple sclerosis].

Machine translation Machine translation
作者 Cadavid D, Tang Y, O'Neill G -More
类别 Primary study
期刊Revista de neurologia
Year 2010
連結 Pubmed
简介：标准的做法已经在复发性多发性硬化症（MS）的形式来衡量扩展残疾状态量表（EDSS）确定的临床病情加重，身体残疾的治疗效果。然而，临床复发，是不是一个可行的选择MS的，因为他们的低频率渐进形式。因此，在临床试验的渐进形式的MS标准方法一直使用的主要成果措施的EDSS评分。 患者与方法：我们研究的EDSS评分的反应疾病进展和治疗效果，在继发进展（，SPMS）和小学逐步（PPMS）MS的临床试验中，多发性硬化症的三大职能任务相比，它的综合功能（MSFC）的定时25脚走路（T25FW），9孔聚乙二醇（9HP），和节奏的听觉序列注意测试（PASAT介入）。 结果：该两个安慰剂年后EDSS评分的影响大小是两者之SPMS和PPM，类似9HP的PASAT介入仅0.2-0.3。相比之下，规模效应的T25FW更大和学科无法完成的任务在很大程度上带动。 结论：EDSS评分显示反应不佳疾病的进展和监察制度和PPM的治疗效果。建议使用替代的主要成果措施逐步MS的治疗试验。
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Epistemonikos ID: 09c9597e39e0ebfc495f57ceaa3a06f357dfd790
First added on: Jan 31, 2012
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