Does the pulse frequency of transcutaneous electric nerve stimulation (TENS) influence hypoalgesia? A systematic review of studies using experimental pain and healthy human participants.

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作者 Chen C, Tabasam G, Johnson MI -More
类别 Systematic review
期刊Physiotherapy
Year 2008
連結
背景：术前放化疗（CRT）对晚期食管胃腺癌的疗效和安全性仍然存在疑问，这些患者的预后差。方法：我们从1990年1月至2014年7月系统搜索电子数据库。主要结果是总体生存。次要结局为R0切除率，淋巴结转移阳性率，术后复发率，病理完全缓解率（PCR）和围手术期死亡率。用危险比（HR）测量总生存期，而以优势比（OR）测量其他次要结果。结果：对785例随机对照试验（RCT）进行了检索，其中869例为腺癌。接受术前CRT的患者总体生存期较长（HR 0.74; 95％置信区间（CI）0.63-0.88），R0切除术的可能性更高，pCR的机会较大，而淋巴结转移和术后复发的可能性较低。围手术期死亡率差异无统计学意义。此外，两例RCT术前CRT和术前化疗（CT）比较的结果不显着。结论：可切除食管胃腺癌患者可以从术前CRT获得生存优势。然而，仅限于RCT的数量，单独添加放射治疗术前CT的效果仍然不确定，需要更高质量的前瞻性试验。
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Epistemonikos ID: 03dc03d7fdb79981fc88f7948d84af7c07d789a1
First added on: Oct 21, 2016
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