Progesterone efficacy for twin preterm labor prevention: a systematic review

The goal of our study was to make a systematic review of randomized controlled trials that analyzed the efficacy of progesterone to reduce preterm birth in twin pregnancies published from 1994 to 2014. According to predetermined criteria, ten studies were included, with a total of 3,432 pregnant woman with twins randomized either to treatment with progesterone versus placebo or no treatment, among which only one study showed benefits, but with a very small sample. We conclude, from this study, that there is no evidence that progesterone prevents twin preterm birth, in general. More studies, that focus the use of progesterone in high risk twin pregnancies, such as short cervix or/and preterm birth history, are required.