Completing the folate biosynthesis pathway in Plasmodium falciparum: p-aminobenzoate is produced by a highly divergent promiscuous aminodeoxychorismate lyase.

Ainda não traduzido Ainda não traduzido
Autores
Categoria Primary study
RevistaThe Biochemical journal
Year 2013
Enzymes that produce or recycle folates are the targets of widely used antimalarial drugs. Despite the interest in the folate metabolism of Plasmodium falciparum, the molecular identification of ADCL (aminodeoxychorismate lyase), which synthesizes the p-aminobenzoate moiety of folate, remained unresolved. In the present study, we demonstrate that the plasmodial gene PF14_0557 encodes a functional ADCL and report a characterization of the recombinant enzyme.
Epistemonikos ID: 916cb66288eff89c335410615409ad5559025d04
First added on: Oct 12, 2024