Indinavir concentrations and St John's wort.

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Categorie Primary study
TijdschriftLancet (London, England)
Year 2000
St John's wort reduced the area under the curve of the HIV-1 protease inhibitor indinavir by a mean of 57% (SD 19) and decreased the extrapolated 8-h indinavir trough by 81% (16) in healthy volunteers. A reduction in indinavir exposure of this magnitude could lead to the development of drug resistance and treatment failure.
Epistemonikos ID: 9b3c6d0585106e56d8b5c4131d8879ede6cc5b17
First added on: Mar 19, 2018