Effects of androgen deprivation therapy duration and gleason grade on survival outcomes of high risk prostate cancer

The meta-analysis has enhanced the evidence for using a longer duration of ADT in a high-risk patient with PCa. However, it could be difficult to apply these results to actual practice due to the various limitations of this study. A high-quality study should be conducted to determine the difference in survival outcome due to the differences in ADT duration according to Gleason group. In conclusion, new anti-androgen or strategies of treatments for maximizing the efficacy of ADT while minimizing its duration should be explored.