[Contribution of specific immunoglobulin anti-D to prophylaxis of haemolytic disease of the newborn].

Specific immunoglobulin anti-D has been used since 1969 at the Filantropia Obstetrical and Gynaecological Clinic in Bucharest. Administration is carried out by the intramuscular route, each ampoule containing 200 microg of specific immunoglobulin anti-D. Of 1,164 observations, 445 mothers had received the treatment. 425 of whom were treated at the time of the birth of their first child and 4 after an abortion. 16 other cases were women treated at the time of a second birth. The therapy was at first limited to primiparas but has now been extended to multiparas and to patients presenting with abortions, ectotropic pregnancies or retention of dead ova. when it was possible that the child would have been Rh positive. The Kleihauer test has been abandoned except in cases where considerable blood transfer could occur between the fetus and the mother, justifying an increase in the therapeutic doses. The results appear to be extremely satisfactory.