Mucolytic treatment of cystic fibrosis - A review of the literature

Dornase alfa (rhDNase) catalysing extracellular DNA hydrolysis is the drug which is currently the most effective in changing the physical and chemical properties of CF sputum. It is a recombinant form of a natural human pancreatic enzyme - deoxyribonuclease (DNase I). The recommended dose is 2500U (2,5 mg) once daily using a jet nebuliser. The drug is well tolerated by most patients. Studies have shown that, in comparison to a placebo group, patients receiving this drug experience fewer respiratory tract infections and hospitalizations, improved lung function and quality of life. © 2006 by Polskie Towarzystwo Pediatryczne.