La vitamina D y calcio reduce las caídas en mujeres de edad avanzada a través de la mejora de balanceo de la carrocería y la normalización de la presión arterial; un estudio prospectivo, aleatorizado y doble ciego

Categoría Estudio primario
RevistaOsteoporosis International
Año 2000
The risk of fractures increases with age. This is a result of increasing bone fragility due to osteoporosis but it is also a result of an increasing number of falls, Consequently, therapeutic interventions should either increase bone mass and bone quality or decrease the risk of falling. The effects of e¡ght weeks of supplementation with vitamin D and calcium on body sway, blood pressure, and biochemical measures of bone metabolism were studied. The sample consisted of 148 women (mean [+-SD] age, 74+-1 years) with a 25-hydroxy-cholecalciferol level below 50 nmol/. They received either 1200 mg of calcium plus 800 |U of vitamin D or 1200 mg of calcium per day. We measured 25- hydroxyvitamin D, intact parathyroid hormone, markers of bone tumover, and blood pressure before and after treatment. Falls and ftactures among the participants were followed over a oneyear period. Statistical evaluation was carried out using SAS for Windows, version 6.10 (CCDRD, Berlin, Germany). Compared to calcium mono, supplementation with vitamin D and calcium resulted in an iñcrease in serum 25-hydroxyvitamin D of 72 percent (p<0.0001), a decrease in parathyroid hormone of 18 percent (p=0.0432), a decrease in body sway of 9 percent (p=0.0435), a decrease in systolic blood pressure of 9 percent (p =0.0165), and a decrease in heart rate of 5 percent (p=0.0219). The mean number of falls per subject during a one year follow-up period was 0.45 for the calcium mono group and 0.24 for the calcium and vitamin D group (p= 0.0346). Short-term supplementation with vitamin D and calcium improves body sway, normalizes blood pressure, reduces secondary hyperparathyroidism and therefore may prevent falls and subsequent nonvertebral fractures in elderly women.
Epistemonikos ID: 54c2ba720f0ebec9df1cd093476f81727b7a1510
First added on: Nov 26, 2015