A randomized controlled trial of CPET-based individualized home exercise training in patients with connective tissue disease-associated pulmonary arterial hypertension

INTERVENTION: Intervention group:Personalized home exercise programs based on cardiorespiratory exercise test results;Control group:Standard medication therapy and standard medical care; CONDITION: Connective tissue disease‐associated pulmonary arterial hypertension PRIMARY OUTCOME: peak VO2; SECONDARY OUTCOME: NT‐proBNP;Short Form 36‐Item Health Survey;Skeletal muscle content;emPHasis‐10;6‐minute walk distance;Exercise‐Related Adverse Events;Mini Nutritional Assessment;Cardiopulmonary exercise test (CPET); INCLUSION CRITERIA: 1.Age >= 18 years; 2.A definitive diagnosis of a connective tissue disease; 3.Right heart catheterization confirmed Class I pulmonary arterial hypertension, defined as mean pulmonary artery pressure (mPAP) > 20 mmHg, pulmonary artery wedge pressure (PAWP) <= 15 mmHg, and pulmonary vascular resistance (PVR) > 2 Wood units; 4.Patients who have been receiving targeted therapy for stable pulmonary arterial hypertension and basic treatment for connective tissue disease for >=3 months, and whose condition is assessed as stable; 5.Has not engaged in regular, structured exercise for the past three months; 6.Voluntarily participate in this study and sign the informed consent form.