Single Session Personalized Aperiodic Transcranial Alternating Current Stimulation (PandA-tACS) for Antenatal Depression

The purpose of this study is to evaluate the safety, feasibility, tolerability, and braineffects of a single session of a personalized form of non‐invasive brain stimulationcalled PandA‐tACS in individuals with antenatal depression. PandA‐tACS uses eachparticipant's own EEG activity to create an individualized stimulation waveform.Participants will be females aged 18‐45 years who are 14‐32 weeks pregnant with a viable,low‐risk singleton pregnancy and meet criteria for unipolar, non‐psychotic majordepressive disorder. Participants must be at low suicide risk, and be able to completestudy procedures.Participants will complete screening, informed consent, clinical assessments, pregnancysafety review, and high‐density EEG recordings. Eligible participants will attend onein‐person stimulation visit and will be randomized to receive PandA‐tACS, individualizedalpha‐frequency tACS, or sham stimulation. Stimulation will be delivered through scalpelectrodes while participants are monitored by trained study staff. EEG, symptom ratings,blood pressure, pre‐natal safety checks, and adverse event monitoring will be completedbefore and/or after stimulation. Optional MRI may be completed for electric‐fieldmodeling. Pregnancy and birth outcomes will be reviewed through the medical record.