Endovascular reperfusion followed by Immediate Acupuncture for Acute Ischemic Stroke: a multi-center randomized controlled trial

INTERVENTION: Acupuncture :Acupuncture + Endovascular thrombectomy and standard treatment.;Sham Acupuncture :Sham acupuncture + endovascular thrombectomy and standard treatment.; CONDITION: Acute anterior circulation large vessel occlusion stroke PRIMARY OUTCOME: mRS score 0 to 1 at 90 (±7) days; SECONDARY OUTCOME: mRS score 0 to 2 at 90 (±7) days;Ordinal mRS shift;NIHSS score at 7 days or early discharge;Health‐related quality of life [EQ‐5D] at 90 (±7) days; INCLUSION CRITERIA: 1)Age: 18–80 years; 2)Presenting with acute ischemic stroke (AIS) symptoms within 24 hours from symptom onset or time last known well; 3)Free of disability before the stroke onset (mRS score of 0‐1) 4)Baseline National Institutes of Health Stroke Scale (NIHSS) score between 5 and 25; 5)Occlusion of the intracranial internal carotid artery, M1 segment or M2 segment of middle cerebral artery (MCA), as confirmed by CTA, MRA or DSA; 6)Baseline Alberta Stroke Program Early CT Score (ASPECTS) = 6 based on non‐contrast computed tomography (NCCT); 7)Treated with emergency EVT resulting in near‐complete to complete recanalization (expanded Thrombolysis In Cerebral Infarction [eTICI] 2b‐3); 8) Informed consent obtained from patients or their legal representatives.