Anticoagulation with argatroban and prostacyclin compared to unfractionated heparin and prostacyclin during continous venovenous haemodialfiltation: a crossover trial

INTERVENTION: Trade Name: Argatra Pharmaceutical Form: Concentrate for solution for infusion Trade Name: Heparin Immuno Pharmaceutical Form: Intravenous infusion CONDITION: Anticoagulation with argatroban and prostacyclin compared to unfractionated heparin and prostacyclin during continous venovenous haemodiafiltarion: a crossover trial PRIMARY OUTCOME: Main Objective: Comparison of duration of filter life during venovenous haemodiafiltration with anticoagulation with argatroban and prostacyclin or unfractionated heparin and prostacyclin Primary end point(s): duration of filter life span during continous venovenous haemodiafiltration Secondary Objective: INCLUSION CRITERIA: a) aged over 18 b) requiring continous renal replacement therapy Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) yes F.1.3.1 Number of subjects for this age range