A pilot study on prevention of glucocorticoid induced diabetes mellitus by linagliptin

INTERVENTION: Concomitant administration of linagliptin at start of GC administration CONDITION: Patients scheduled administration of glucocorticoid PRIMARY OUTCOME: Proportion of development of glucocorticoid induced diabetes mellitus within 1 month SECONDARY OUTCOME: Concomitant insulin use; Concomitant anti‐diabetic drug; Adverse effect; Change in HbAic; Change in HOMA‐IR; Change in glycoalbumin; Change in 1.5‐AG; Change in adiponectin; Change in glucagon; Change in cortisol; Change in leptin; Change in serum and urine CPR INCLUSION CRITERIA: 1) Administration of 20mg/day or more of prednisone is scheduled 2) Not fulfilled below criteria for diabetes mellitus a) HbA1c >= 6.5 % b) fasting blood glucose level >= 126 mg/dL c) blood glucose level at 2hr on OGTT >= 200mg/dL or casual blood glucose level >= 200mg/dL 3) At least either one of following risk factor for glucocorticoid induced diabetes mellitus a) eGFR =< 60ml/min/1.73m2 b) 65 year or older c) HbA1c > 6.0 % 4) Informed consent is obtained