The effect of oliceridine fumarate on postoperative recovery quality and pain in patients undergoing laparoscopic radical resection for colorectal cancer

Authors
Category Primary study
Registry of TrialsChinese Clinical Trial Register
Year 2026
INTERVENTION: Oliceridine Group:When closing the skin after the operation,patients in Group O received intravenous injection of 2mg of oliceridine fumarate Injection;Fentanyl Group:When closing the skin after the operation,patients in Group F received intravenous injection of 0.1mg fentanyl citrate injection; CONDITION: colorectal cancer PRIMARY OUTCOME: QoR‐40; SECONDARY OUTCOME: First exhaust time within 24 hours after surgery;Number of rescue analgesia cases in both groups within 24 hours after surgery;First press time of postoperative analgesia pump;The first compression time of the postoperative analgesia pump was 30 minutes (T6), 2 hours (T7), 6 hours (T8), 12 hours (T9), and 24 hours (T10) after extubation, and VAS scores were obtained during rest and coughing;Number of cases treated with gastric lavage for antiemetic relief within 24 hours after surgery in both groups;Morphine equivalents of patients in the two groups within 24 hours after surgery;The first time for the patient to get out of bed after surgery;The incidence rates of postoperative nausea and vomiting, skin itching, dizziness and headache in patients;Surgery time and postoperative extubation time;Intraoperative remifentanil dosage; INCLUSION CRITERIA: 1. Age range: 18‐80 years old; 2. ASA classification II‐III; 3. Planned elective laparoscopic radical resection for colorectal cancer.
Epistemonikos ID: fe0bf238167942d53172ccfbbb472b2affd2e41b
First added on: Jun 06, 2026