Management of Post-Induction Hypotension in Emergency Abdominal Surgery

Authors
Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2025
The goal of this clinical trial is to compare the efficacy of two vasopressors (norepinephrine vs. ephedrine) in treating hypotension in adult patients (aged 18+, ASA I-III) undergoing general anesthesia for abdominal surgical emergencies (e.g., appendicitis, intestinal obstruction, peritonitis). The main questions it aims to answer are: * Which drug is more effective at maintaining intraoperative blood pressure (SBP ≥ 80% of baseline)? * How many boluses of each vasopressor are required to maintain target blood pressure? Researchers will compare the norepinephrine group (receiving 10 µg boluses) to the ephedrine group (receiving 6 mg boluses) to see if norepinephrine is superior for maintaining hemodynamic stability and reduces the number of interventions needed. Participants will: * Be randomly assigned to receive one of the two study drugs. * Undergo standard general anesthesia with close hemodynamic monitoring. * Receive boluses of the assigned vasopressor whenever their blood pressure drops below a predefined threshold.
Epistemonikos ID: fd8aa8596a1ebdba9bf7770c02043790c7e23d92
First added on: Dec 03, 2025