Evaluation of the effect of Misswake herbal mouthwash in children with cystic fibrosis

INTERVENTION: Intervention 1: Intervention group: Measurement of periodontal indices, prophylaxis, fluoride therapy and oral hygiene education (toothbrush and toothpaste), mouthwash. Intervention 2: Control group: Measurement of periodontal indices, prophylaxis, fluoride therapy and oral hygiene education (toothbrush and toothpaste). CONDITION: Cystic fibrosis. ; Cystic fibrosis PRIMARY OUTCOME: Gingival index. Timepoint: 1 month. Method of measurement: loe & Sillness method. Plaque index. Timepoint: 1 month. Method of measurement: Periodontal indexe. Salivary Intrlukin 1‐beta. Timepoint: 1 month. Method of measurement: Saliva sampling. Simplified Oral Hygiene index. Timepoint: 1 month. Method of measurement: Periodontal index. INCLUSION CRITERIA: A child with a definitive diagnosis of cystic fibrosis who is in the period of mixed dentition (patients 6 to 12 years old). Patients with moderate severity of cystic fibrosis according to the opinion of the attending physician (based on spirometry), without mental problems and metabolic and endocrine diseases, do not take analgesics at the moment, do not have xerostomia and in the next 6 months from products be Oral and dental antimicrobials have not been used.