Meditation for adults with mild cognitive impairment: a pilot randomized trial.

The objectives of the current study were to test the safety and feasibility of mindfulness-based stress reduction (MBSR) in adults with mild cognitive impairment (MCI) and explore the effects of MBSR on cognition and well-being through standardized instruments, neuropsychological evaluations, and interviews. Fourteen subjects were recruited from 2010 to 2011 from the Beth Israel Deaconess Medical Center Cognitive Neurology Unit with the human subjects review board’s approval. To assess safety and feasibility, information was systematically collected on class attendance, home practice logs, and adverse events. Functional magnetic resonance imaging was used to assess measures of brain function and structure; results will be reported elsewhere. This proof-of-concept clinical trial found that adults with MCI can safely participate in and adhere to a MBSR program. The qualitative interviews revealed that most enjoyed the program and described improved mindfulness skills, well-being, interpersonal skills, and acceptance and awareness of MCI and decreased stress reactivity.