Influence of CYP3A4-induction by St. John's Wort on the Steady State Pharmacokinetics of Bosentan

Authors
Category Primary study
Registry of Trialsclinicaltrials.gov
Year 2011
The aim of the present study is to assess the impact of the cytochrome P450 2C9 (CYP2C9) genotype (\*2 and \*3 allele versus wild type; \~3-5% poor metabolisers in Caucasian population) on the pharmacokinetics of bosentan and the impact of CYP3A4-induction by St. John\'s wort (SJW) on steady state bosentan which is a CYP3A4 inducer itself.
Epistemonikos ID: fae4bc523af7f8204b165951c67917556c188c94
First added on: May 06, 2024