Buyuan Yizhi Granules for Mild Cognitive Impairment (Syndrome of Marrow Insufficiency and Phlegm-Turbidity): A Randomized Controlled Clinical Trial

Authors
Category Primary study
Registry of TrialsInternational Traditional Medicine Clinical Trial Registry
Year 2026
INTERVENTION: Electroacupuncture group:Buyuan Yizhi Granules (composed of ginseng, ginger‐processed pinellia tuber, etc.; administered continuously for 8 weeks, once every other day, 4 days per week) plus finger exercises (10–15 minutes before and after each herbal treatment, 4 times per week, 32 sessions in total over 8 weeks).;Waiting Treatment Group:During the observation period, only finger exercise training was performed 4 times per week (synchronized with the treatment group), 10–15 minutes each time. Upon completion of the observation period, 8 weeks of free electroacupuncture treatment was provided.; CONDITION: Amnestic mild cognitive impairment PRIMARY OUTCOME: Alzheimer's Disease Assessment Scale ‐ Cognitive Subscale; SECONDARY OUTCOME: Montreal Cognitive Assessment Scale;Mini‐Mental State Examination (MMSE) Scale Score;Activities of Daily Living Scale Scoring;Pittsburgh Sleep Quality Inde XScale; INCLUSION CRITERIA: 1.Meet the Western medical diagnostic criteria for mild cognitive impairment and the traditional Chinese medical diagnostic criteria for the marrow insufficiency and phlegm‐turbidity pattern; 2.Aged 40 to 80 years old (inclusive), with no gender restriction; 3.Right‐handed, free of visual and auditory impairments, and able to cooperate with scale assessments; 4. No participation in other clinical trials in the past 3 months, no long‐term use of specific medications before enrollment, or completion of the washout period; 5. Voluntarily participate in the study and sign the informed consent form.
Epistemonikos ID: fae38c7ba9cd17bf2fd6c6bc8ae49c5cce1bf82d
First added on: Jul 21, 2026