Pilot Study on the Efficacy of Two Intraperitoneal Ondansetron Formulations for Postoperative Pain Management After Laparoscopic Choleycstectomy.

This study is a randomized pilot trial designed to evaluate the efficacy of two different intraperitoneal formulations of ondansetron in managing postoperative pain following laparoscopic cholecystectomy. Patients undergoing this procedure will receive one of two formulations of ondansetron, either combined with bicarbonate or a saline solution, during surgery. The primary objective is to determine which formulation more effectively reduces pain in the first 24 hours post-surgery. Secondary outcomes include the need for rescue analgesics, the frequency of nausea and vomiting, and the safety profile of the interventions. This study aims to improve postoperative pain management and reduce the need for additional pain medications.