Evaluating the effect of propolis tablets on chemotherapy induced oral mucositis

INTERVENTION: Control group: receives pelacebo Intervention 1: Intervention group: administration of oral propolis tablet 50mg,twice a day(BID) up to 21 days. Intervention 2: Control group: receives pelacebo. Intervention group: administration of oral propolis tablet 50mg,twice a day(BID) up to 21 days. Placebo Treatment ‐ Drugs CONDITION: chemotherapy induced oral mucositis. ; oral mucositis ( drug induced ) oral mucositis ( drug induced ) PRIMARY OUTCOME: Severity of oral mucositis. Timepoint: once a week (weekly ). Method of measurement: according to WHO and OMAS indices. SECONDARY OUTCOME: _. Timepoint: _. Method of measurement: _. INCLUSION CRITERIA: INCLUSION CRITERIA: Patients with colon cancer who receive Folfox chemotherapy regimen with oral mucositis at grade 0 level from WHO indice. Exclusion criteria: Chronic liver failure(stage2,3); Chronic kidney disease(stage4,5); Oral signs and symptoms of any type of allergy and sensitivity to honey and propolis.