Plasma DNA Methylation for Preoperative Classification of Renal Masses

Authors
Category Primary study
Registry of TrialsClinicalTrials.gov
Year 2026
METH-RENAL is a prospective observational diagnostic development and threshold-setting study in adults with a renal mass scheduled for partial or radical nephrectomy. Peripheral blood is collected before surgery, and postoperative histopathology serves as the reference standard. The study will develop and internally validate a plasma DNA methylation classifier and lock the final marker panel, algorithm, and positivity cut-off for a subsequent independent prospective multicenter validation study.
Epistemonikos ID: fa0167345f5b567d321fdd13a2977d5aa5ea9609
First added on: Oct 16, 2026