Japanese Diastolic Heart Failure Study

INTERVENTION: Treatment without beta‐blocker. Until the end of this study, Treatment with beta‐ blocker Until the end of this study CONDITION: Diastolic heart failure PRIMARY OUTCOME: a composite of cardiovascular death and unplanned admission to hospital for congestive heart failure SECONDARY OUTCOME: all cause mortality; worsening of the symptoms (that is defined by either a decrease by 1 Mets or over in the SAS questionnaire score or an increase by I class or over in the NYHA functional class for at least 3 months as compared with the baseline); an increase in brain natriuretic peptide (BNP) by 30% or over of the value at the randomization in patients with BNP of 200 pg/ml or over at the randomization; unplanned admission to hospital for congestive heart failure, or a need for modification of the treatment for heart failure (changes in oral medicine for at least one month or addition of intravenous inotropes for at least 4 hours) INCLUSION CRITERIA: 1, Clinical diagnosis of heart failure based on a slight modification the Framingham criteria as previously described1 within 12 months before the entry. 2, Documentation of LV ejection fraction > 40% when diagnosed as heart failure 3, No change in baseline therapy and symptoms of heart failure within a month