Tofacitinib vs oral non-steroidal anti-inflammatory drugs in the treatment of inflammatory knee osteoarthritis: a randomized, open-label, multicenter, controlled study

INTERVENTION: intercention group:Addition of Topoteb to the original treatment;control group:Oral anti‐inflammatory and analgesic drugs; CONDITION: inflammatory osteoarthritis PRIMARY OUTCOME: OMERACT‐OARSI;Erythrocyte sedimentation rate;hsCRP; SECONDARY OUTCOME: Untralsound evaluation of synovitis;MRI Synovitis Score; INCLUSION CRITERIA: 1. Aged over 40 years; 2.The patients should fufill the 1995 ACR osteoarthritis classification criteria. 3. Knee joint swelling, tenderness and increased skin temperature as judged by physicians; 4. Poor response to conventional anti‐inflammatory and analgesic drug treatment for 4 weeks; 5. Peripheral erythrocyte sedimentation rate is higher than 28mm/h or high sensitive C reactive protein is over 8mg/L; 6. B‐ultrasound or knee MRI clear evidence of synovitis.