Study on the pharmacodynamic interactions between propofol and sevoflurane during induction of anesthesia.

INTERVENTION: Trade Name: Diprivan Product Name: Diprivan Pharmaceutical Form: Emulsion for infusion INN or Proposed INN: Propofol CAS Number: 2078‐54‐8 Concentration unit: mg/ml milligram(s)/millilitre Concentration type: equal Concentration number: 10‐ Trade Name: Sevorane Product Name: Sevorane Pharmaceutical Form: Inhalation vapour, liquid INN or Proposed INN: Sevofluraan CAS Number: 28523‐86‐6 Concentration unit: % percent Concentration type: equal Concentration number: 100‐ CONDITION: Anesthesia PRIMARY OUTCOME: Main Objective: To investigate the pharmacodynamic interaction between propofol and sevoflurane. Primary end point(s): Pharmacodynamic clinical effects:; * hypnotic (as measured by computerised EEG); * analgesic (movement in response to different clinically relevant noxious stimuli) Secondary Objective: INCLUSION CRITERIA: American Society of Anesthesia class I and II patients 18‐60 years Scheduled for surgery under general anesthesia Are the trial subjects under 18? no Number of subjects for this age range: F.1.2 Adults (18‐64 years) yes F.1.2.1 Number of subjects for this age range F.1.3 Elderly (>=65 years) no F.1.3.1 Number of subjects for this age range